Oncogene-targeted drugs such as vemurafenib and dabrafenib for BRAFV600 mutated melanoma, and immune checkpoint inhibitors targeting immunomodulatory molecules such as ipilimumab, the anti-cytotoxic-T-lymphocyte associated protein 4 (CTLA-4), and nivolumab and pembrolizumab, the anti-programmed cell death 1 (PD-1) have completely revolutionized the treatment of advanced melanoma in recent years. Here, CTLA4 is linked to melanoma.