In male Sprague-Dawley rats, infusion of NEfor seven days reduce the expression of myosin heavy chain 11, myosin light chain 3 and troponin I. In patients with heart failure, the expression of a number of sarcomeric genes decreases, while their expression is restored in those having left ventricular assisted device (Rodrigue-Way et al., 2005). The gene discussed is MYL3; the disease is heart failure.