Among the genes downregulated by ISO, were those associated with hypertrophic, dilated, and arrhythmogenic right ventricular cardiomyopathy (Bar I1: 19 genes, Bar J1: 17 genes, and Bar K1: 24 genes); Huntington’s (Bar M1: 31 genes), Parkinson’s (Bar N1: 27 genes), and Alzheimer’s diseases (Bar O1: 29 genes); type II diabetes (Bar P1: eight genes). This evidence concerns the gene GRK2 and early-onset autosomal dominant Alzheimer disease.