Meanwhile, there were specific pathways in each treatment group, for example, there were four specific pathways in JU groups, including Mucin expression in CF via IL-6, IL-17 signaling pathways, transcription-role of vitamin D receptor (VDR) in regulation of genes involved in osteoporosis, regulation of cystic fibrosis transmembrane conductance regulator (CFTR) activity 9 (norm and CF), development-granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling (Figure 2). This evidence concerns the gene CSF2 and osteoporosis.