Explorative or consensus studies (Onofrj et al., 2002; Diederich et al., 2005; Goetz et al., 2011) have analyzed the time of appearance, prevalence, and correlation of VH with ongoing cognitive decline (Barnes et al., 2003; Ramirez-Ruiz et al., 2006; Ramirez-Ruiz et al., 2007; Barnes and Boubert, 2008) and indicated that VH are associated with and predict the presence of α-synuclein (i.e., Lewy bodies) deposits (Harding et al., 2002; Williams and Lees, 2005; Halliday et al., 2011). This evidence concerns the gene SNCA and Mental deterioration.