AKT1 and Alzheimer disease: The effect of the DHA enriched diet on amyloid Aβ1–40 levels was accompanied by modified expression of components of a neuroprotective signaling pathway implicated in the AD pathology, the PI3K/Akt/GSK3 cascade and of key synaptic proteins like synapsin and PSD95 (Gomez-Sintes et al., 2011; Reddy, 2013; Llorens-Martin et al., 2014; Beurel et al., 2015).