Changes in the dietary DHA intake reduce the amyloid burden in the brain of AD mouse models (Lim et al., 2005; Green et al., 2007), and we previously showed that different concentrations of n-6 and n-3 LC-PUFAs in the diet modify the brain levels of APP in WT mice (Herrera et al., 2018). The gene discussed is APP; the disease is Alzheimer disease.