IL-10, also known as cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine upregulated in AD patients (Guillot-Sestier et al., 2015). Overexpression of IL-10 in AD animal models reduces microglial phagocytosis of Aβ leading to cognitive impairment (Chakrabarty et al., 2015; Guillot-Sestier et al., 2015). This evidence concerns the gene IL10 and Alzheimer disease.