IFNG and Alzheimer disease: IFN-γ is a proinflammatory regulatory cytokine that activates microglia. It is primarily produced by T cells and natural killer cells but can also be secreted by microglia and astrocytes (Fultz et al., 1993). IFN-γ is upregulated in the AD brain (Huberman et al., 1994) and a polymorphism is associated with fast progressing AD, suggesting it could play a detrimental role in the course of AD (Asselineau et al., 2015).