ZIC1 and schizophrenia: For example, Zic genes are strongly expressed in the cerebellum and have been shown to mediate cerebellar development (Aruga and Millen, 2018), and behavioral abnormalities of Zic1 mutant mice can serve as models for diseases involving sensorimotor gating abnormalities, such as schizophrenia (Ogura et al., 2001).