Major hallmarks in Alzheimer’s disease (AD) are the presence of paired helical filaments of tau protein (PHFTau) within neurons, also known as neurofibrillary tangles (NFTs), and aggregates of amyloid-β protein (Aβ) which form plaques in the extracellular space (Grundke-Iqbal et al., 1986; Goedert et al., 1988; Avila, 2004; Hyman et al., 2012; Takahashi et al., 2017). The gene discussed is MAPT; the disease is Alzheimer disease.