Since DD is associated with a partial loss of enteric neurons and a lack of the nerve growth factor GDNF with concomitant intestinal motility disturbances, we raised the question whether the NRG1 growth factor system and the enteric nAchR subunit composition are also altered in DD, thereby contributing to the intestinal hypoganglionosis and motility dysfunctions in DD. Here, CHRNA4 is linked to dentin dysplasia.