Some studies have reported that the NLRP3 inflammasome is involved in the activation of M1 microglia after stroke (Ji et al., 2017), and the conversion processes of procaspase-1 to caspase-1 also contributes to the production and secretion of M1 typed mature pro-inflammatory cytokines (Slusarczyk et al., 2018). This evidence concerns the gene NLRP3 and Stroke.