TNF and Fever: NF-κB is a transcription factor activated by TLR agonists and cytokines, such as TNF-α, and is thought to be a key regulator of neuroinflammation (Mincheva-Tasheva and Soler, 2013) and fever, since NF-κB-deficient mouse do not develop a fever after LPS injection (Kozak et al., 2006; Rummel, 2016).