TARDBP and amyotrophic lateral sclerosis: Although RRM1-2 are structurally well-folded and mostly known for interaction with nucleic acids, several studies have now suggested the presence of amyloidogenic cores and the ability of these domains to misfold and participate in either nucleation or propagation of TDP-43 aggregation in ALS (Shodai et al., 2012, 2013).