Of particular interest, TDP-43 has been shown to regulate its own mRNA (Ayala et al., 2011), the alternative splicing of hnRNPA1 mRNA (Deshaies et al., 2018), key cryptic exon splicing of C9orf72 (Buratti et al., 2001) -the well-known hexanucleotide GGGGCC repeat expansion and the most frequent genetic cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD) (Balendra and Isaacs, 2018), Tau splicing resulting in accumulation of disease-associated isoform (Gu et al., 2017, 2018). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.