TARDBP and amyotrophic lateral sclerosis: SUMOylation was suggested to be a pathological event in ALS, since superoxide dismustase 1 (SOD1), Fused in Sarcoma (FUS) and TDP-43 were found SUMOylated (Dangoumau et al., 2013; Foran et al., 2013) which resulted in an increase aggregation of those proteins.