TARDBP and amyotrophic lateral sclerosis: Given the proximity between oxidation sites and the disease-exposed regions of TDP-43 retrieved in ALS patients (166–173 and 246–255) as well as cleavage sites, the early misfolding of TDP-43 by oxidation, upstream of ubiquitination, phosphorylation, and fragmentation, as suggested in Cohen et al. (2012), is an attractive hypothesis.