The mechanisms through which HFD might influence depression- and anxiety-like behaviors are not completely understood, but preclinical work has suggested a potential role of HFD-induced alterations in GSK3β signaling (Papazoglou et al., 2015; Wakabayashi and Kunugi, 2019) and brain inflammation (Dutheil et al., 2016; Wu et al., 2018). This evidence concerns the gene GSK3B and Anxiety.