ATG12 and Alzheimer disease: In the first study, an increase of mTOR along with a reduction of ATG7 (but not beclin-1, ATG5 or ATG12) was detected in DLB vs. AD brains (Crews et al., 2010) whereas in the latter study, an increase of LC3II was observed in DLB but not AD patients, a reduction of LAMP2 levels being common (Higashi et al., 2011).