Notably, neurodegenerative disorders of aging such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD) frontotemporal dementia and amyotrophic lateral sclerosis are characterized by a common feature: accumulation of aberrant or misfolded proteins, such as α-synuclein (α-syn), Aβ, tau, mutant forms of huntingtin, TDP43, which are neurotoxic (Gal et al., 2009; Bourdenx et al., 2017; Boland et al., 2018). Here, TARDBP is linked to Huntington disease.