LRRK2 and neuroblastoma: That LRRK2 modulates autophagy was shown for the first time by Plowey et al. (2008) in SH-SY5Y neuroblastoma cells overexpressing WT LRRK2, G2019S LRRK2 (a kinase-enhancing mutation) (West et al., 2005; Greggio et al., 2006), or K1906M LRRK2, a kinase dead (KD) mutation (Table 1).