In rodent models, zinc deficiency is associated with cell cycle arrest, mediated in part through dysregulation of the ERK1/2, p53, and NF-kappa B pathways, and zinc deficiency during development is associated with both impaired neuronal precursor cell proliferation and induction of apoptosis (Corniola et al., 2008; Gao et al., 2009; Adamo and Oteiza, 2010). This evidence concerns the gene MAPK3 and Zinc deficiency.