Moreover, post-mortem brain samples from individuals with C9orf72 positive ALS find a positive correlation between the magnitude of expression of CD86 and Iba1, markers of microglia activation and proliferation, and the severity of ALS symptomology and magnitude of TDP-43 deposition (Brettschneider et al., 2012). The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.