SOD1 and amyotrophic lateral sclerosis: Post-mortem specimens from individuals with SOD1 linked fALS and individual with spontaneous ALS, elevated oxidative damage markers OH8dG were found to occur in neurons from both sporadic ALS and familial ALS patients, suggesting ROS and microglia pathology as a commonality between forms of sporadic and fALS (Ferrante et al., 1997).