Other SOD1 ALS-related metabolic changes have previously been reported, including differences in cerebrospinal fluid metabolomes with SOD1-fALS patients (Wuolikainen et al., 2012), and neurometabolic changes in cervical spinal cords of asymptomatic mutant SOD1-positive individuals similar to those observed in patients with clinically apparent ALS (Carew et al., 2011). Here, SOD1 is linked to amyotrophic lateral sclerosis.