However, the tau pathology in AD is known to begin in areas such as the dorsal raphe nuclei (Grinberg et al., 2009) and the locus coeruleus (Satoh and Iijima, 2019) or it can also begin in the area of the neocortex rather than the medial temporal lobe (Braak and Braak, 1991; Lewis and Dickson, 2016). Here, MAPT is linked to Alzheimer disease.