NCOA4 and hydrops fetalis: Brain ferritin has FTH1 as the predominant subunit of its normal ferritin 24-mer assembly, and it is possible that imbalance in the ratio of mtFTL and/or wtFTL to FTH1 subunits caused by HF, i.e., a decrease in normal ferritin FTH1 subunit content in the 24-mer, could substantially and negatively affect NCOA4 binding to ferritin and its clearance by ferritinophagy.