FTH1 and hydrops fetalis: Importantly, Ftl−/− mice show that because FTH1 ferritin homopolymers can maintain brain iron homeostasis in a mouse model, there is the potential for development of a therapeutic approach for HF treatment using RNA interference to induce sequence-specific post-transcriptional gene silencing of mutant FTL or alternatively both, wild-type and mutant FTL alleles (Li et al., 2015).