A mouse model of HF (FTL-Tg) that expresses the human mutant ferritin FTL subunit p.Phe167SerfsX26 (mtFTL) has been extensively characterized and also used to generate astrocytes and primary mouse embryonic fibroblasts for in vitro studies (Barbeito et al., 2009; Li et al., 2015) that complemented studies using fibroblasts from patients with HF (Barbeito et al., 2010). This evidence concerns the gene FTL and hydrops fetalis.