AKT1 and neoplasm: Activated AKT not only can transduce antiapoptotic signals by phosphorylating and inactivating key proteins involved in cell proliferation and survival, making it difficult to control tumor progression, but also affects cell proliferation via modulation of the cell cycle machinery and regulation of the activity of the cyclin D1 kinase glycogen synthase kinase-3β(GSK-3β) [18].