POU3F2 and hepatocellular carcinoma: Meanwhile, the results from TCGA database indicated that POU3F2 was highly expressed in HCC patients (n = 375) compared to normal (n = 50), and its high expression was easily led to unfavorable prognosis in HCC patients (Fig. 4c, P < 0.0001, Fig. 4d, P = 0.0083).