ATP1B1 and cancer: ATP1B1 is a Na+/K+‐transporting ATPase that is required for maintaining a normal polarised epithelial phenotype.63, 64 Decreased ATPase function is associated with epithelial‐to‐mesenchymal transition, which is essential to numerous developmental processes, and in the initiation of metastasis in cancer progression.65, 66 Hypoxic regulation of ATP1B1 could have implications in cancer pathogenesis.