Previously the ZFHX3 gene was found to be associated with AF presence in a heart failure population.12 Our comprehensive AF genetic risk score of 97 SNPs, together with the estimation that 22.9% of the phenotypic variance is explained by additive genetic variation, provide evidence of a substantial contribution of genome‐wide variation to AF susceptibility in heart failure patients. Here, ZFHX3 is linked to atrial fibrillation.