Eight COPD susceptibility genes (CBX5, MIDN, FAM136A, NUFIP2, HMGN2, MPLKIP, MICA, and RLIM) and seven COPD susceptibility lncRNAs (LINC00654, AC020978.8, AP006284.1, AC145207.5, NPTN-IT1, PSMD6-AS2, and ADAMTSL4-AS1) were identified as COPD susceptibility biomarkers. The gene discussed is HMGN2; the disease is chronic obstructive pulmonary disease.