The ICM susceptibility genes enriched in four ICM-related functional classes could classify samples accurately, including cardiovascular disease, which was associated with coronary angiogenesis and vascular endothelial growth factor receptor [41]; inflammatory immune, which was capable of causing myocardial ischemic injury [42]; metabolism, which was related to the phosphorylation of PI3K and Akt in myocardial tissue of cardiomyopathy [43], and cell polarity, one of the fundamental causes of congenital heart disease [44]. The gene discussed is AKT1; the disease is congenital heart disease.