CD69 expression was in part restored (~30%) by CD8+ T cells after the anti-PD1 mAb block, but this amelioration of CD69 expression did not correlate with levels of PD-L1 protein carried by MTEX in melanoma patients (r = −0.01, P = 0.98) or with expression levels of any of the other immunoregulatory proteins we evaluated (data not shown). The gene discussed is CD274; the disease is melanoma.