Conditioning on AF attenuated the HF risk effect by >50% for the PITX2/FAM241A locus but not other AF-associated loci (KLHL3, SYNPOL2/AGAP5), conditioning on CAD fully attenuated effects for two of the six CAD loci (LPA, 9p21/CDKN2B-AS1) and conditioning on body mass index (BMI) ablated the effect of the FTO locus (Supplementary Fig. 4, Supplementary Data 5). The gene discussed is PITX2; the disease is atrial fibrillation.