SYNPO2L and familial dilated cardiomyopathy: We identified a missense variant in BAG3 (rs2234962; r2 = 0.99 with sentinel variant rs17617337) associated previously with DCM and progression to HF, and three missense variants in SYNPO2L (rs34163229, rs3812629 and rs60632610; all r2 > 0.9 with sentinel variant rs4746140)10,11,27.