We identified a missense variant in BAG3 (rs2234962; r2 = 0.99 with sentinel variant rs17617337) associated previously with DCM and progression to HF, and three missense variants in SYNPO2L (rs34163229, rs3812629 and rs60632610; all r2 > 0.9 with sentinel variant rs4746140)10,11,27. This evidence concerns the gene SYNPO2L and hydrops fetalis.