Among HF loci not associated with CAD, a group of four clustered together, of which two (KLHL3 and SYNPO2L/AGAP5) were associated with AF and two (BAG3 and CDKN1A) with reduced LV systolic function (fractional shortening (FS); Bonferroni-corrected P < 0.05); we highlight the results for these loci in our reporting of subsequent analyses to identify candidate genes. This evidence concerns the gene AGAP5 and hydrops fetalis.