NR1H4 and type 2 diabetes mellitus: The effects of M on our bile acid profile is consistent with published studies showing M reducing bile acid gut reabsorption in T2D patients64, with some studies suggesting M effects on bile acid profile is via ileal protein transporters65, reducing ileal bile salt reabsorption66, or influencing crosstalk processes between the nuclear bile acid receptor farnesoid X receptor and the nutrient-sensitive kinase, 5′ adenosine monophosphate-activated protein kinase67.