It has been reported that the AMPK and mTOR, master regulators of cellular energy and insulin signalling, highlight the association between the metabolic alterations and chemoresistance, and provide ideal targets for intervention.6–8 Calcium-binding protein 39 (CAB39), a scaffold protein of liver kinase B1 (LKB1), is a key regulatory factor upstream of AMPK/mTOR pathway.9 Although the mechanism of CAB39 in regulating the conformation of STE20 kinases and activating catalytically competent protein kinases has been identified, the roles of CAB39 in CRC have not been discussed.10 Here, MTOR is linked to colorectal carcinoma.