In this study, we found that a novel miR-107/CAB39/AMPK/mTOR signalling axis regulates L-OHP resistance in CRC cells, and that DCA can effectively increase L-OHP sensitivity partly through this signalling pathway, which may aid in the design of optimal chemotherapy strategies to increase the treatment efficacy for CRC (Fig. 6f). Here, CAB39 is linked to colorectal carcinoma.