The PDX models generally conserved the established prognostic molecular markers and recurrent aberrations observed in the original tumour, including chromosome 1p loss and 17q gain, MYCN and ALK amplification and loss of PHOX2B, TP53, NF1 and ATRX (Fig. 1c and Supplementary Fig. S1A, B). This evidence concerns the gene MYCN and neoplasm.