Strikingly, these changes were accompanied by significant ameliorations in the histological and clinical scores of arthritis (Fig. 3g), marked decreases in enthesitis-associated ankle thickening (Fig. 3g) and new bone formation (Supplementary Fig. 3b), and inhibition of the bone surface:volume ratio increase (Fig. 3g), highlighting an anti-GM-CSF-mediated reduction in inflammation-associated bone damage26. Here, CSF2 is linked to enthesitis.