The loss of RhoB, a downregulated gene in animals treated with tesa-NPY compared to [F7, P34]-NPY, has been shown to prevent streptozotocin-induced diabetes and ameliorate diabetic complications in mice, which could indicate the positive effects of tesa-NPY in the absence of HbA1c differences between the delay in disease progression in animals under treatment [112]. The gene discussed is NPY; the disease is diabetes mellitus.