Compared with participants with lower serum Dkk-3 levels, those with higher Dkk-3 levels were more likely to be older and male; have higher creatinine; have higher prevalence of history of coronary heart disease and lacunar stroke; have lower diastolic BP, body mass index, total cholesterol, triglyceride, and blood glucose; and have lower prevalence of alcohol drinking, family history of stroke, and thrombotic stroke (the analysis of variance or Kruskal-Wallis test for continuous variables and χ2 test for categorical variables reveal p < 0.05; Table 1). This evidence concerns the gene DKK3 and coronary artery disorder.