HK2 and colorectal carcinoma: To verify the roles of HK2 in promoting the glycolysis and proliferation of CRC cells, we silenced HK2 expression in HCT116 and LoVo cells (Fig. 8a) and found that cell growth (Fig. 8b) andcolony formation (Fig. 8c) were inhibited, and cell cycle arrest was induced(Fig. 8d).