The results of Fig. 5e showed that the protein expression of hMSH2 and PTEN in the tumor tissue was rescued by the THLG-EXO/miR-21i and THLG-EXO/5-FU/miR-21i, while the solely delivered 5-FU by THLG-EXO had almost no noticeable effect on the expression of hMSH2 and PTEN. The gene discussed is MSH2; the disease is neoplasm.