ERBB2 and neoplasm: To monitor the tumor targeting property of the exosomes for the Her2-positive tumor bearing mice, the in vivo DiR labeled THLG-EXO and LG-EXO were monitored in real-time in live animals using a fluorescence imaging system (Xenogen, Alameda, CA, USA) with the excitation and emission wavelength of 750 and 780 nm respectively.