Furthermore, an increasing number of in vitro and in vivo studies has also consistently shown that increasing the levels of SELENBP1 significantly suppresses the malignant characteristics of cancer cells, leading scientific community to the consensus that SELENBP1 may act as a putative tumor suppressor involved in the regulation of cell proliferation, senescence, epithelial–mesenchymal transition, migration and apoptosis [23]. This evidence concerns the gene SELENBP1 and neoplasm.