CDKN1A and cancer: Given that c-Jun responsive element is closely located at the potential STAT1 binding sites in the promoter of p21, it is intriguing to further determine whether there is a physical interaction between c-Jun and STAT1 in the context of SELENBP1-mediated p21 expression, and the results from which would improve our understanding of the tumor-suppressive role for SELENBP1 in cancer.