SELENBP1 and Familial prostate cancer: Since the initial report identifying SELENBP1 as a tumor-associated protein in prostate cancer [8], the reduced expression or even lost of SELENBP1 has been consistently observed in a variety of solid tumors as compared to corresponding normal tissues, including those of the skin [9], lung [10], esophagus [11], stomach [12–14], colon [15, 16], liver [17], breast [18] and ovary [19].