Chemotherapy agents interfering with EGFR or FGFR pathways have known ocular side effects such as acquired trichomegaly, persistent corneal epithelial defects, dysfunctional tear syndrome, blepharitis, meibomitis, iridocyclitis, and lid ectropion, etc. [1, 2, 4] However, recent articles have reported the appearance of epithelial changes after EGFR inhibitor chemotherapy, including vortex keratopathy, a whorl-like pattern of corneal haziness [5, 6]. The gene discussed is EGFR; the disease is iridocyclitis.