This aortic risk is reportedly caused by the loss of function of extracellular matrix proteins (associated pathway “Extracellular matrix organization”), such as collagens and elastin of the vascular wall (associated pathway “Crosslinking of collagen fibrils”), that leads to the loss of solidity and elasticity of the blood vessels, including the aorta, ultimately causing thoracic aortic aneurysm. Here, ELN is linked to thoracic aortic aneurysm.