Specifically, BTF3 was confirmed aberrantly in various cancer tissues such as gastric cancer tissues [47, 48], prostate cancer tissues [49], colorectal cancer tissues[50] and pancreatic cancer cells [51]; RPS16 was found dysregulated in disc degeneration, which is one of the main causes of low back pain [52]; HSF1 influenced the expression of heat shock proteins as well as other activities like the induction of tumor suppressor genes, signal transduction pathway, and glucose metabolism. Here, BTF3 is linked to Familial prostate cancer.