PTEN and cancer: For example, PTEN is a tumor suppressor and mutated in a large number of cancers at high frequency, and PTEN deletion, mutation, and loss of PTEN expression were of clinical significance in de novo DLBCL.48 As a result, we investigated the prognostic performance of PTEN in OSdlbcl at both RNA and DNA levels, and the results showed that PTEN is an independent favorable prognostic factor for OS at the RNA level (HR = 0.67, P < .05) (Figure 2A), while PTEN mutation is the independent prognostic factor for poorer survival in DLBCL (HR = 0.11, P = .04) (Figure 2B).