VEGF binds to the VEGF receptor (VEGFR), stimulates VEGFR‐mediated downstream signaling, and ultimately leads to tumor angiogenesis.6 It is thought that VEGFR and human epidermal growth factor receptor 1 (HER‐1)/epidermal growth factor receptor (EGFR) share a common downstream signaling pathway, so EGFR‐TKI can also downregulate VEGF. This evidence concerns the gene KDR and neoplasm.