Variants of the two family members (PLCγ1 and PLCγ2) have been linked to cancer, complex immune disorders, inflammation (further implicated in other diseases such as cancer and steroid-sensitive nephrotic syndrome) as well as Alzheimer's and related neurodegenerative diseases; the major, comprehensive discoveries are described in a number of publications including [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]. The gene discussed is PLCG2; the disease is cancer.