The Wnt/β‐catenin signaling pathway plays a key role in the pathogenesis of various human diseases and tumors.23 LGR6 promotes the progression and invasion of lung cancer and high‐grade serous ovarian carcinoma, as well as the stemness and chemoresistance of ovarian cancer cells through this mechanism.18, 19, 26 LGR6 may contribute to the development and progression of ESCC by activating the Wnt/β‐catenin signaling pathway, but further research is needed to confirm this hypothesis. The gene discussed is LGR6; the disease is esophageal squamous cell carcinoma.