ZNRF3 and neoplasm: ZNRF3 (interaction score: 0.960) and RNF43 (interaction score: 0.960) act as negative regulators of the Wnt signaling pathway and inhibit tumor progression.23 UBC and UBB are mainly involved in the ubiquitination of eukaryotic cells, a series of processes including protein degradation, DNA repair, transcription, protein transport, cell cycle regulation, and signal transduction.