Hauser AS and Lappano R et al reported that G protein–coupled receptors and membrane signaling proteins including LGR6 are good candidates for cancer‐targeting molecular therapies.25, 26 Our results suggest that LGR6 may be a potential therapeutic target for ESCC, providing a potential therapeutic strategy by increasing the degradation or reducing the expression of LGR6 to interfere with tumor progression. The gene discussed is LGR6; the disease is esophageal squamous cell carcinoma.