LGR6 and rectum adenocarcinoma: Next, we studied the expression differences in LGR6 mRNA in 31 human cancers compared with normal tissues based on the TCGA and UCSC data sets and found that LGR6 mRNA expression was significantly higher in colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), glioblastoma multiforme (GBM), ovarian serous cystadenocarcinoma (OV), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), and stomach adenocarcinoma (STAD) tissues than in the corresponding normal tissues (Figure 2).