LGR6 has been widely reported to be an important stem cell marker in many cancer types that promotes the occurrence and progression of cancer.19, 20 Paradoxically, LGR6 has been reported to act as a tumor suppressor gene in colon and breast cancers.21, 22 These results suggest that the role of LGR6 in tumors is related to the tumor type. This evidence concerns the gene LGR6 and breast cancer.