We explored the functional effects and potential molecular mechanisms of LGR6 on ESCC progression by using the University of California Santa Cruz (UCSC) and the Cancer Genome Atlas (TCGA) data, constructing a protein‐protein interaction (PPI) network and performing Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. The gene discussed is LGR6; the disease is esophageal squamous cell carcinoma.