Some associations co-occurred in 2 traits (Fig 2D), namely for CAD and stroke at TWIST1, for CAD and AAA at IL6R, for CAD and migraine at PHACTR1, and for migraine and AAA at LRP1. LRP1 and IL6R play well-described roles in vascular biology and disease [24, 25]. The gene discussed is IL6R; the disease is migraine disorder.