Genes preferentially expressed in HCASMCs were from lineage-specific pathways such as epithelial-to-mesenchymal transition, myogenesis, angiogenesis and hepatic fibrosis (Table 1); HCAEC-specific genes were in Notch, eNOS and VEGF signaling pathways (S2 Table). The gene discussed is VEGFA; the disease is Hepatic fibrosis.