Some associations co-occurred in 2 traits (Fig 2D), namely for CAD and stroke at TWIST1, for CAD and AAA at IL6R, for CAD and migraine at PHACTR1, and for migraine and AAA at LRP1. LRP1 and IL6R play well-described roles in vascular biology and disease [24, 25]. This evidence concerns the gene IL6R and stroke disorder.