Indeed, we found a significant overlap between genes downregulated in LN stroma of Deaf1-knockout mice and FRCs in acute GVHD, although this comparison is limited by differences in mouse strains used to identify regulated genes (BALB/c for Deaf1 knockout because B6 mice are not viable after birth) and the relative lack of purity of the stroma analyzed (18). Here, DEAF1 is linked to acute graft versus host disease.