NFKB1 and acute graft versus host disease: Although there were some differences (for example, increased expression of pathways relating to NF-κB activation in acute GVHD), we observed remarkably similar changes in gene expression in FRCs early following herpes simplex virus (HSV) infection (27), suggesting that components of the transcriptional response represent default programs triggered by inflammation (Supplemental Figure 1; supplemental material available online with this article; https://doi.org/10.1172/JCI133102DS1).