Transfer of CD62L– T cells was effective at preventing GVHD in the B6→129 BMT model (Supplemental Figure 3A) and also induced significantly less depletion of the FRC population than nonmanipulated T cells (Figure 3B); this effect was also observed when the input T cell numbers were adjusted to allow equal representation of CD4+ and CD8+ T cell subsets between the experimental cohorts (data not shown). This evidence concerns the gene CD8A and graft versus host disease.