However, as fibrates have many mechanisms of action and the liver is not the only organ affected during sepsis (Morel & Singer, 2014; Tancevski et al, 2014; Camara‐Lemarroy et al, 2015), it is essential to study the role of the liver in the protection of pemafibrate during sepsis, for example via the use of PPARα hepatocyte‐specific knock‐out animal models. The gene discussed is PPARA; the disease is Sepsis.