SIRT1 and chronic obstructive pulmonary disease: On the contrary, increased expression and activity of SIRT1 prevent cells from entering into the state of senescence by inhibiting p53 activity.37 Furthermore, it has been shown that inhibition of miR‐570‐3p in small airway epithelial cells from COPD patients restores SIRT1 expression, leading to SIRT1‐dependent inhibition of senescence markers and cellular rejuvenation.38