For example, increased p16 expression was described in the glomerular cells during glomerular diseases, such as glomerulonephritis, membranous nephropathy, diabetic nephropathy and focal segment glomerular sclerosis.58, 59 In addition, vascular and interstitial cells may undergo senescence during glomerular diseases and hypertension.58 Therefore, different stressors that occur on different site may decide the localization and type of senescent cells. The gene discussed is CDKN2A; the disease is glomerular disorder.