KL and chronic kidney disease: Conversely, mice with overexpression of Klotho gene exhibit longer lifespan.32 If Klotho is exogenously administered, the senescence of endothelial cell can be significantly reduced.33 Interestingly, the levels of Klotho were significantly decreased in old patients (80‐89 years) with CKD compared to patients with CKD at the age of 60‐69; serum Klotho levels were inversely correlated with age, suggesting that Klotho may serve a biomarker of ageing progression.34