Furthermore, serum lactate levels from Ndufs3 smKO mice at 3, 6, and 8 months were dramatically increased, demonstrating that Ndufs3 smKO mice suffered from severe lactic acidosis (Fig 2D), a common feature in patients with mitochondrial myopathies (Rowland et al, 1991). The gene discussed is NDUFS3; the disease is Mitochondrial myopathy.