CDKN2A and chordoma: We therefore tested the expression of these candidate miRNAs in monoallelic (n = 16) and disomic (n = 18) chordoma cases that had retained or lost p16 immunoreactivity (Figure 2D–F), but we failed to identify a correlation with p16 expression by IHC, suggesting that other mechanisms yet to be identified control the expression of p16 in chordoma.