LIF secretion was estimated under the control of oestrogen receptor (ER) during embryo implantation.52 Previous studies reported G protein‐coupled oestrogen receptor (GPER) stimulation activates YAP and transcriptional coactivator with a PDZ‐binding domain (TAZ), via the Galphaq‐11, PLCβ/PKC, and Rho/ROCK signalling pathways.53 Moreover, Integrin‐FAK signalling is a novel IL‐6 and LIF regulation mechanism relevant to the inflammation and stem cell fields,54 and also contributes to stem cell‐based tissue renewal regulation55 and tumour budding of colorectal cancer56 in YAP signalling. This evidence concerns the gene PRRT2 and neoplasm.