In this study, serum levels of CHI3L1 were measured in CHB patients, LC patients, and HCC patients and we studied the stage expression characteristics in different stages of chronic liver diseases related to hepatitis B. As Figure 1 shows, the expression levels of CHI3L1 were increased successively from CH to LC to HCC. The gene discussed is CHI3L1; the disease is laryngotracheoesophageal cleft.